Challenges with MOD - Email Campaigns

In today's marketing environment, email is one of many mediums to bring cost-effective value to corporate and agency marketing departments and firms. However, according to Merkle, Inc., a Maryland-based database marketing agency, few marketing executives have fully integrated email into their marketing mix due to a number of common reasons, including:

1. Limited resources monopolized by tactical production issues
2. Too little focus on analytics, program design and measurement
3. Lack of an email address acquisition and channel development strategy
4. Email deliverability issues and difficulties in managing ISP relations
5. Complexities associated with managing data and content

Automating the email campaign process and integrating it with other on-demand marketing mediums, would reduce, if not eliminate, many of the above reasons.

How would you address each of those reasons? I'm curious...